Lipids and Lipid Derivatives
Medchemexpress LLC Ondansetron-d3 (hydrochloride) | 1346605-02-4 | 98.78% | C18H17D3ClN3O | 1 MG
Ondansetron-d3 (hydrochloride) is a deuterium-labeled form of Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) acts as a serotonin 5-HT3 receptor antagonist, primarily used as an antiemetic to prevent and treat nausea and vomiting, often experienced after chemotherapy. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules largely for tracer purposes during drug development and have the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer.
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Skatole-d3 | 111399-60-1 | 134.19 | 1 MG
Skatole-d3 is the deuterium labeled Skatole. It is produced by intestinal bacteria and regulates intestinal epithelial cellular functions by activating aryl hydrocarbon receptors and p38. It is for research use only. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC 1-Methyladenine-d3 | 15763-06-1 | 284.29 | 10 MG
1-Methyladenosine-d3 is the deuterium-labeled version of 1-Methyladenosine. 1-Methyladenosine is an RNA modification that can act as a tumor marker, with elevated levels linked to cancer development. The methylation of 1-methyladenosine leads to the upregulation of PPARδ expression, which regulates cholesterol metabolism and activates the Hedgehog signaling pathway, thereby promoting liver tumorigenesis.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by methods such as NMR, GC-MS, or LC-MS.
- Deuteration is used in drug molecules primarily as tracers for quantitation during drug development.
- Has the potential to influence the pharmacokinetic and metabolic profiles of drugs.